Spray Drying (SD)
Not all spray-drying is equal. Let us show you how our array of equipment employed with deep particle engineering and formulation expertise can improve your drug products.
Features of Spray Drying
- Spray-dried dispersions – API + polymer/excipients
- Spray-dried powders – API alone
- Spray dry from aqueous or organic solvent systems
- Applicable to peptides and biologics
- CritiTech’s single pass nitrogen systems are especially advantageous for oxygen sensitive and hygroscopic compounds
- Non-potent API (dedicated rooms, equipment, and air handling system)
- Non-cytotoxic API (dedicated rooms, equipment, and air handling system)
- Potent API (dedicated rooms, equipment, and air handling system)
- Cytotoxic API (dedicated building, equipment, and air handling system)
- Milligrams to hundreds of kilograms production scale
- Fully validated cGMP equipment
Benefits of Spray Drying
- Bioavailability enhancement of poorly soluble drugs (BCS Class II and IV)
- Modified release rates of highly and poorly soluble compounds
- Enables improved pharmacokinetics and multiple routes of delivery
- Development of multiple formulations with grams of API
- Scalable and reproducible
- Can be utilized as a LCM tool for a reformulated and improved 2nd generation product
- Conditions from Buchi B-290 or Mobile Minor systems can be transferred to CritiTech
CritiTech Spray Drying Systems
Buchi B290 | CritiTech SD30 | CritiTech SD100 | Anhydro MS75 | Anhydro MS150 | |
| Nominal process gas flow | 40 kg/hr | 120 kg/hr | 120 kg/hr | 75 kg/hr | 150 kg/hr |
| Water evaporation capacity | 1.0 L/hr | 3.5 L/hr | 3.5 L/hr | 3 L/hr | 14 L/hr |
| Maximum drying gas pressure | 220°C | 215°C | 215°C | 200°C | 350°C |
| Approximate production scale | 0.25-10 g | 10-250 g/hr | 10-250 g/hr | 10-200 g/hr | 50-2000 g/hr |
| Aqueous processing | ✔ | ✔ | ✔ | ✔ | ✔ |
| Multiple nozzle configurations | ✔ | ✔ | ✔ | ✔ | ✔ |
| Volatile solvent compatible | ✔ | ✔ | ✔ | ✔ | ✔ |
| Non-Cytotoxic | ✔ | ✔ | ✔ | ✔ | |
| Cytotoxic | ✔ | ✔ |
Spray Drying Equipment Details
CritiTech’s Buchi B-290 |
|
| Nominal Process Nitrogen Flow | 40 kg/hr |
| Water Evaporation Capacity | 1.0 L/hr |
| Approximate Batch Scale | 0.25-10 g |
| Aqueous Processing | ✔ |
| Volatile Solvent Compatible | ✔ |
| Multiple Nozzle Configurations | ✔ |
The CritiTech SD30 Spray Drying System provides scaled-up cGMP production from the Buchi B-290. The SD30 consistently reproduces material produced on the Buchi B-290.
CritiTech’s SD30 |
|
| Nominal Process Nitrogen Flow | 120 kg/hr |
| Water Evaporation Capacity | 3.5 L/hr |
| Approximate Batch Scale | 10-250 g/hr |
| Aqueous Processing | ✔ |
| Volatile Solvent Compatible | ✔ |
| Multiple Nozzle Configurations | ✔ |
CritiTech’s Anhydro MS75 |
|
| Nominal Process Nitrogen Flow | 75 kg/hr |
| Water Evaporation Capacity | 3.0 L/hr |
| Approximate Batch Scale | 10-200 g |
| Aqueous Processing | ✔ |
| Volatile Solvent Compatible | ✔ |
| Multiple Nozzle Configurations | ✔ |
CritiTech’s Anhydro MS150 |
|
| Nominal Process Nitrogen Flow | 150 kg/hr |
| Water Evaporation Capacity | 14.0 L/hr |
| Approximate Batch Scale | 50-2000 g |
| Aqueous Processing | ✔ |
| Volatile Solvent Compatible | ✔ |
| Multiple Nozzle Configurations | ✔ |
CritiTech’s SD100 |
|
| Nominal Process Nitrogen Flow | 120 kg/hr |
| Water Evaporation Capacity | 3.5 L/hr |
| Approximate Batch Scale | 10-250 g/hr |
| Aqueous Processing | ✔ |
| Volatile Solvent Compatible | ✔ |
| Multiple Nozzle Configurations | ✔ |