Spray Drying (SD)

Not all spray-drying is equal. Let us show you how our array of equipment employed with deep particle engineering and formulation expertise can improve your drug products.

Features of Spray Drying

  • Spray-dried dispersions – API + polymer/excipients
  • Spray-dried powders – API alone
  • Spray dry from aqueous or organic solvent systems
  • Applicable to peptides and biologics
  • CritiTech’s single pass nitrogen systems are especially advantageous for oxygen sensitive and hygroscopic compounds
  • Non-potent API (dedicated rooms, equipment, and air handling system)
  • Non-cytotoxic API (dedicated rooms, equipment, and air handling system)
  • Potent API (dedicated rooms, equipment, and air handling system) 
  • Cytotoxic API (dedicated building, equipment, and air handling system) 
  • Milligrams to hundreds of kilograms production scale
  • Fully validated cGMP equipment

Benefits of Spray Drying

  • Bioavailability enhancement of poorly soluble drugs (BCS Class II and IV)
  • Modified release rates of highly and poorly soluble compounds
  • Enables improved pharmacokinetics and multiple routes of delivery
  • Development of multiple formulations with grams of API
  • Scalable and reproducible
  • Can be utilized as a LCM tool for a reformulated and improved 2nd generation product
  • Conditions from Buchi B-290 or Mobile Minor systems can be transferred to CritiTech

CritiTech Spray Drying Systems

Buchi B290

CritiTech SD30

CritiTech SD100

Anhydro MS75

Anhydro MS150

Nominal process gas flow40 kg/hr120 kg/hr120 kg/hr75 kg/hr150 kg/hr
Water evaporation capacity1.0 L/hr3.5 L/hr3.5 L/hr3 L/hr14 L/hr
Maximum drying gas pressure220°C215°C215°C200°C350°C
Approximate production scale0.25-10 g10-250 g/hr10-250 g/hr10-200 g/hr50-2000 g/hr
Aqueous processing
Multiple nozzle configurations
Volatile solvent compatible
Non-Cytotoxic
Cytotoxic
Spray Drying Equipment Details

CritiTech’s Buchi B-290

Nominal Process Nitrogen Flow 40 kg/hr
Water Evaporation Capacity 1.0 L/hr
Approximate Batch Scale 0.25-10 g
Aqueous Processing
Volatile Solvent Compatible
Multiple Nozzle Configurations

 

The CritiTech SD30 Spray Drying System provides scaled-up cGMP production from the Buchi B-290. The SD30 consistently reproduces material produced on the Buchi B-290.

 

CritiTech’s SD30

Nominal Process Nitrogen Flow 120 kg/hr
Water Evaporation Capacity 3.5 L/hr
Approximate Batch Scale 10-250 g/hr
Aqueous Processing
Volatile Solvent Compatible
Multiple Nozzle Configurations

 

 

CritiTech’s Anhydro MS75

Nominal Process Nitrogen Flow 75 kg/hr
Water Evaporation Capacity 3.0 L/hr
Approximate Batch Scale 10-200 g
Aqueous Processing
Volatile Solvent Compatible
Multiple Nozzle Configurations

 

CritiTech’s Anhydro MS150

Nominal Process Nitrogen Flow 150 kg/hr
Water Evaporation Capacity 14.0 L/hr
Approximate Batch Scale 50-2000 g
Aqueous Processing
Volatile Solvent Compatible
Multiple Nozzle Configurations

 

CritiTech’s SD100

Nominal Process Nitrogen Flow 120 kg/hr
Water Evaporation Capacity 3.5 L/hr
Approximate Batch Scale 10-250 g/hr
Aqueous Processing
Volatile Solvent Compatible
Multiple Nozzle Configurations