*Unprocessed Paclitaxel
*Processed Paclitaxel (Nanotax)

Improving the Bioavailability
of Poorly Soluble Drugs

CritiTech Particle Engineering Solutions uses its particle engineering technologies and expertise to help customers improve and optimize the bioavailability of poorly soluble drugs. It also helps improve the efficacy, pharmacokinetic (PK) profile, dosing, delivery of drugs, and reduce side effects.

Improving Bioavailability
Through Particle Engineering

CritiTech Particle Engineering Solutions uses its Supercritical Precipitation and Spray Drying technologies to enable a wide range of and improved pharmaceuticals with multiple drug dosage and delivery options.

Reduce
Particle Size
Increase
Surface Area
Improve
Dissolution Rate
Optimize
Bioavailability

Supercritical
Precipitation Technology

Having processed over 70 drugs from a variety of drug classes, CritiTech’s Supercritical Precipitation Technology has been proven to be an effective tool for solving some of the toughest solubility problems.  The technology can be helpful in advancing a promising but poorly soluble new chemical entity or as a lifecycle management strategy to provide a reformulated and improved 2nd generation product.

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Spray Drying Technology

Spray drying has gained wide-spread acceptance and support as a key technology for use in formulation and drug development. Spray drying has become the fastest growing platform used to address solubility problems, including proteins, peptides and monoclonal antibodies. It is applicable to a variety of drug delivery options as a result of the ability to produce dry powder amorphous solid dispersion API at high throughput levels. CritiTech Particle Engineering Solutions offers Proof of Concept to cGMP spray drying services, including cytotoxic and potent compounds.

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Analytical Laboratory Services

To better meet the needs of our clients, CritiTech Particle Engineering Solutions announces the expansion of our on-site characterization, testing and analytical services at our primary facility in Lawrence. With our expansion, we are now able to offer extensive on site capabilities to our clients to save time and money in the development of drugs.

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Why CritiTech
Particle Engineering Solutions?

  • Pre-clinical to Phase II clinical production capabilities
  • Experience producing cGMP material for three Phase II trials
  • Rapid project turnaround
  • 10,000 sq ft Facility for research, analytical, and cGMP production
  • Clients ranging from “Top 10 Pharma” to start-up companies
  • Lawrence, KS – Home of the University of Kansas School of Pharmacy
  • Client focused staff

What solubility problem can CritiTech help you solve?

Contact Us

Contact Us

To discuss how CritiTech can help your company overcome solubility issues that you are facing, please contact us today.

Larry Dickinson
Chief Commercial Officer
785-841-7120
ldickinson@crititech.com