Particle Engineering For Drug Development

There is more to solving bioavailability challenges than just particle size

When developing pharmaceuticals, particle engineering plays an important role. Many active ingredients are not easily absorbed into the body unless the size and surface area of the individual particles are engineered to have particular dimensions. CritiTech provides drug particle engineering services that create pharma products that will have the greatest efficacy once introduced into the bloodstream. Our particle engineering capabilities can have a significant impact on how well a drug is dissolved, absorbed and performs, ensuring the highest levels of bioavailability.

CritiTech combines its pharmaceutical particle engineering experience and technologies, spray drying and supercritical precipitation, to help our clients develop their drugs and achieve their target product profiles.  One of our key strengths is addressing the solubility and bioavailability challenges associated with poorly-soluble compounds. CritiTech’s Bioavailability Optimization Team partners directly with customers to develop innovative solutions for overcoming solubility problems. Beyond that, our customers leverage our drug particle engineering expertise and technologies to achieve their product specifications in several areas including:

• Particle Size
• Particle Shape
• Crystalline and/or Amorphous Phase
• Surface Area
• Solubility
• Dissolution
• Flowability
• Efficacy
• Toxicity
• Dosing
• Route of Administration

Our team has incorporated JMP software to assist with our particle engineering. JMP has enhanced our design of experiments, hypothesis testing, analytic methods and reliability modeling.

Why Choose CritiTech for Particle Engineering?

Customers throughout the pharmaceutical industry count on us to provide expert particle engineering that solves their challenges. We take a problem-solving approach to every project, and our expertise gives our particle engineers the ability to take on even the most complex requirements. With advanced technologies spray drying and supercritical precipitation, we offer the ability to create a fully customized solution for your precise needs. If you would like to know more about everything we can do for you, reach out and speak with one of our representatives today.

Examples of Engineered Particle Shape, Size, Structure & Morphology

Modification of particle shape – this is the same drug using different processing conditions:

An array of shapes, sizes and structures can be produced through particle engineering – these are 8 different drugs:

Modifying morphology – this is the same drug in different processing conditions: